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9. Anne Hathaway in Les Miserables
The heart-wrenching role won Anne an Oscar award in 2013, but portraying the character left Anne with some personal struggles. Her intense transformation portrayed the character of Fantine, a starving French woman, perfectly. Anne lost 25 pounds for the role but did not expect the toll the weight loss would take on her mental health. In an interview with Vogue, the actress admitted that she took a long time to bounce back and be able to cope with life again. She also admits to facing an identity crisis after transforming for her role.